Formulation and Evaluation Herbal Gel from Psidium Guajava and Jasminium Officinali for Mouth Ulcer Treatment

Abstract

India has long employed traditional or herbal medicine to diagnose, treat, and prevent illness. The study\'s objective was to create and assess a herbal gel that contained extract from jasmine officinale and Psidium guajava for the treatment of mouth ulcers. Herbal gel made using powdered extracts of Psidium guajava and Jasminum officinale at varying concentrations. Psidium guajava has high antifungal and antibacterial action and is used to treat a number of illnesses, including diabetes mellitus, diarrhea, rheumatism, wounds in the throat, and coughs. Tannins, flavonoids, triterpene, quercetin, pentacycline, triterpenoids, gujanoic acid, saponins, carotenoids, lectin, ellugic acid, sitosterol, and oleanolic acid are found in Psidium guajava leaves, whereas the properties of Jasmine Officinale include analgesic, antioxidant, anti-inflammatory, stomachic, astringent, stimulating, and sedative effects. Alkaloids, tannins, terpenoids, glycosides, steroids, essential oil, and saponin are among its constituents.Guava and jasmine leaf extracts, Carbopol 934, propylene glycol, propyl paraben, methyl paraben, triethanolamine, and distilled water were used to make the herbal gel formulation. To keep the pH between 7 and7.5, triethanolamine was added. The evaluation\'s viscosity, homogeneity, PH, and spreadability parameters. The gel strength and extruadability were ascertained.The results indicate that all assessment parameters found to be acceptable with the normal range were discovered in the optimized herbal gel formulation containing extracts from guava and jasmine leaves. For the treatment of oral ulcers, the herbal formulation proved to be more stable, safe, and successful than the synthetic formulation.

Introduction

I. INTRODUCTION

The semi-solid substance is called a gel. Gel formulations are used to apply localized or topical medication penetration to specific mucosal regions.

Due to the high alcohol content and the presence of some chemical compounds, gel active agents that are synthetic or semi-synthetic produce burning sensations and various forms of tooth sensitivity.Gels and jellies are made out of a small amount of solid ingredients that resemble liquid ingredients. Herbal gel is becoming more and more popular for treating and preventing mouth ulcers, but synthetic gel could include several dangerous chemicals that have serious negative effects. Due to its safety as goods or homemade formulas, herbal cosmetics are becoming more and more popular around the world. Gel can prevent gastrointestinal pH-related problems with medicine absorption in the gastrointestinal tract. A more drastic strategy for making herbal gel more widely used would be to alter customer expectations by placing more of a focus on efficacy and safety. This research focuses on the development, content, and assessment techniques of herbal mouth ulcer gel. Aphthous ulcers are another name for mouth ulcers. An ulcer (aphthous) that develops on the oral cavity's mucous membrane. Mouth ulcers are quite frequent, arising from a variety of diseases and causes, but typically have no significant underlying cause. It is not always indicative of oral cancer if a mouth ulcer heals quickly.

A. Symptoms of Mouth Ulcer

1. Edema surrounding the ulcer.
2. More pain when you wash your teeth.
3. Pain that gets worse when one eats spicy food.
4. Pain causing difficulty when brushing or biting teeth.
    

B. What Causes Mouth Ulcers?

It is unknown exactly what causes mouth ulcers. However, a number of things can lead to the formation of these sores, including:
Minor tissue damage resulting from dental procedures, such filling a cavity.

1. Biting your tongue or cheek by accident.
2. Allergic response to specific microorganisms.
3. Using retainers or braces for orthodontics.
4. Deficits in vitamins.
5. Using toothpaste that is rough or harsh.
6. Consuming an abundance of acidic foods, such strawberries, pineapples, and oranges.
7. variations in hormones during menstruation.
8. Tension.
9. Insufficient sleep.

C. Advantages of Mouth Ulcer Gel

1. Pain Respite: Anesthetic compounds, which are frequently found in mouth ulcer gels, offer momentary respite from the pain and suffering that come with ulcers.
2. Promotes Healing: Certain gels have components that could hasten the healing of mouth ulcers.
3. Topical Application: By applying gels directly to the afflicted region, the ulcer is targeted without having an impact on the body as a whole.

D. Disadvantages of Mouth Ulcer Gel

1. Temporary Relief: Gels only provide short-term relief; they might not deal with the mouth ulcer's underlying cause.
2. Texture and Taste: The gel's taste and texture may not be to everyone's liking, which might make application uncomfortable.
3. Allergy Reactions: Some people may be allergic to some of the gel's chemicals, which could cause them more discomfort.
4. Not Suitable for Extreme Cases: Professional medical intervention may be required in extreme cases or when ulcers are an indication of an underlying problem.
5. Short Duration of Action: The gel's effects are sometimes transient, necessitating repeated applications to provide long-lasting relief.

II. PLANT PROFILE

A. Guava Leaves

Peru, Amrood, and Guava are other names for Psidium Guajava. It is a member of the Myrtaceae family of medicinal plants. The dimensions of guava leaves are 3-5 cm by 7-15 cm. It is used to treat a number of illnesses, including diabetes mellitus, rheumatism, diarrhea, sore throats, and coughs. It also has strong antifungal and antibacterial properties. Tannins, triterpene, flavonoids, quercetin, pentacycline, triterpenoids, gujanoic acid, saponins, carotenoids, lectin, ellugic acid, sitosterol, and oleanolic acid are all present in Psidium Guajava leaves.

C. Formulation Table

The composition of herbal prepared from powered extract of guava and jasmine leaves coded as F1, F2 and F3 is tabulated in table 1.

Table 1: Composition Of Gel

D. Evaluation Parameter

1. Physical Appearance

Physical parameter such as color odor and consistency

Color: color of the formulation was checked by visual inspection.

Oduor: The odor of the formulation by olfactory sensation.

Consistency:The consistency of formulation was checked by applying on skin.

2. Measurement of pH

The pH of herbal gel formulations were determined by using digital pH meter. 1 gm of gel was taken and dispersed in 10 ml of distilled water and keep aside for 2 hours.

3. Homogeneity

All developed gel formulations were tested for homogeneity by visual inspection after the gels have been set in to the container. They were tested to check presence and appearance of any aggregate.

4. Extrudability

The gel formulations were filled in standard capped collapsible aluminum tubes and sealed to the end. The Extrudability was determined by pressing of the thumb.

5. Clarity

The clarity of all the three batches was determined by visual inspection.

6. Spread ability

The spread ability was measured by spreading of 0.5 g of the gel on a circle of 2 cm diameter premarket on a glass plate and then a second glass plate was employed. 100gm of weight was permitted to rest on the upper glass plate.

IV. RESULTS AND DISCUSSION

Formulation and evaluation herbal gel was prepared.

A. Observation Table

Table no:2

Conclusion

The data presented in the study; it was demonstrated that the developed herbal gel formulation possess significant, therapeutically efficacious, suitable vehicle for drug delivery in low cost but definitely with high potential. Developed new herbal gel formation is suitable for mouth ulcers treatment.

References

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Copyright

Copyright © 2024 Miss. Gayatri B. Gaware, Prof. Rahul S. Mohan, Dr. Rajendra M. Kawade. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.